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We have a middle-aged immunocompromised male presenting with neutropenic fevers, progressive cough and dyspnea. He has no sick contacts or recent travel.

He was found to have primarily right upper alveolar opacities and blunting of the right costophrenic angle. He rapidly decompensated with acute hypoxemic respiratory failure requiring mechanical ventilation. A CT chest showed dense consolidations with air bronchograms.

The urinary antigen and sputum culture were positive for Legionella and the patient was continued on Macrolide therapy. See our infographic for high-yield teaching points for Legionnaires’ Disease